Abstract
Effective and safe treatment is preconditioned by distinguishing type 1 and type 2 amiodarone-induced thyrotoxicosis. Type 1 should be treated with methimazol and the therapeutic response is prolonged.
Based on recent knowledge, immediate discontinuation of amiodarone is not routinely recommended, and patients should be usually prepared to total thyroidectomy. Eventually, radioiodine treatment may be planned if there is appropriate accumulation.
Type 2 is treated with glucocorticoids, and has a rather prompt therapeutic response (within 1 - 2 weeks), more often with permanent remission or progression to hypothyroidism, and amiodarone (without clear cardiologic indication) may be discontinued after several weeks. Amiodarone-induced hypothyroidism is treated with levothyroxine substitution without amiodarone interruption.