Publikace na 1. lékařská fakulta, 2. lékařská fakulta |
2018
Abstrakt
Iron is an essential nutrient and iron deficiency results in anemia as well as poor neurodevelopment in children. However, iron is not routinely provided in pediatric parenteral nutrition (PN) mixtures and is usually not a component of commercially available trace element preparations.
The major concern is that of iron overload. Parenteral administration of iron bypasses the homeostatic control of gastrointestinal iron absorption, causing loss of protection from iron overload if excessive quantities are provided, since humans have no mechanism for excretion of iron.
Iron overload has been reported in children receiving prolonged PN and is associated with increased oxidative stress and increased risk of infections.