Acral peeling skin syndrome is a rare disease with unknown prevalence and with dozens of cases described in the medical literature so far. Here we report a case of acral peeling skin syndrome in a young man confirmed histologically and by mutational analysis.
A 28-year-old man, a laboratory technician, was referred with a possible diagnosis of glove-related contact dermatitis as an occupational disease. However, the patient reported a life-long history of superficial skin peeling and vesiculation on the dorsal aspects of hands and feet, provoked by perspiration in gloves, prolonged soaking in water or exposure to heat and/or slight pressure, with a tendency to heal spontaneously within 48 hours.
He also complained of a slight burning sensation at the site of skin eruptions.