Aggressive TFEB-rearranged renal cell carcinoma mimicking chromophobe and clear cell renal cell carcinoma
Abstract
MiT family translocation renal cell carcinoma (RCC) includes Xp11 translocation RCC and t(6;11) RCC. The t (6;11)RCC exhibits MALAT1-TFEB gene fusion and is less common than Xp11 translocation RCC.
Typical t(6;11) RCC shows solid alveolar growth composed of eosinophilic large cells mixed with clear cells, and rosette-like structures composed of lymphocyte-like small cells around an eosinophilic basement membrane material. Tubular and papillary architecture could also be seen in some parts.
However, t (6;11) RCC may possibly have variable morphological patterns, such as Xp11.2 RCC. Some t(6;11) RCCs were reported to resemble clear cell RCC (CRCC),1 chromophobe RCC (ChRCC),1 and Xp11.2 translocation RCC.2 Recently, it was suggested that TFEB-amplified RCC is a unique tumor type.3,4 Some t(6;11) RCCs with TFEB amplification have been reported, and it was suggested that some RCCs develop in older patients with aggressive behavior, compared to t(6;11) RCC without TFEB amplification.2,3 To our knowledge, this is the first report of recurrent TFEB-rearrangement RCC with TFEB amplification mimicking ChRCC and CRCC.