Histological, haematological and biochemical evaluation of samples after application of antiseptic dental yarn to the rabbit gum
Abstract
Aims: Verification of safety and degradation of hyaluronan-based dental antiseptic yarn in an in vivo environment on a rabbit model by blood sample analysis (blood count, leukocyte differential budget, CRP, total protein, albumin, ALT, AST, GMT, ALP, creatinine, urea) histological examination of internal organs (liver, kidney, heart, spleen, lungs) and histological examination of the gums at the site of insertion of the test preparation. Conclusion:
1) Experimental animals showed no signs of deprivation during the experiment neither any negative impact of implanted material.
2) Hematological and biochemical examination of blood taken before implantation of the material and after the required residence time of the material does not indicate a negative effect on the cellular component of the blood, respectively on biochemical markers of internal organ failure.
3) The test results do not indicate that the tested medical device has any negative effect on the internal organs of the animal or on the soft tissues around it.
4) As expected, the individual modifications of the test material degraded differently. Material was found at the implant site after 2 weeks, but after 4 weeks no remainder of the implant was found.
5) Material that was older than 8 months showed significantly faster degradation in vivo