In the first part of the book Thus Spoke Zarathustra Nietzsche speaks of two kinds of selfishness: low egoism is faced with pure self-giving, the bestowing love. This new virtue creates new values that replace the former virtues of the weak.
Thus, Zarathustra himself must overcome his last sin, his compassion: with the rope-dancer, with the ugliest man, and finally with the higher man.Compared to the two kinds of selfishness, there are two different ways of overcoming compassion. One is its absolute rejection, when this emotion is to be eliminated as a degenerate, ill, perverted and decreasing the man.
The second, interpretative option then is to overcome compassion in terms of its re-evaluation and transformation, of taking control of the compassion, where the candidate for such an analogous disposition seems to be the bestowing virtue.