Identifying demographic, social and clinical predictors of biologic therapy effectiveness in psoriasis: a multicentre longitudinal cohort study
Abstract
Eight factors associated with reduced odds of achieving >= 90% improvement in Psoriasis Area and Severity Index (PASI 90) at 6 months were identified (described as odds ratio and 95% confidence interval): demographic (female sex, 0.78, 0.66-0.93); social (unemployment, 0.67, 0.45-0.99); unemployment due to ill health (0.62, 0.48-0.82); ex- and current smoking (0.81, 0.66-0.99 and 0.79, 0.63-0.99, respectively); clinical factors (high weight, 0.99, 0.99-0.99); psoriasis of the palms and/or soles (0.75, 0.61-0.91); and presence of small plaques only compared with small and large plaques (0.78, 0.62-0.96). White ethnicity (1.48, 1.12-1.97) and higher baseline PASI (1.04, 1.03-1.04) were associated with increased odds of achieving PASI 90.
The findings were largely consistent at 12 months. There was little evidence for predictors of differential treatment response.