The presented invention is a prophylactic preparation containing 2,3-dehydrosilybin A, 2,3-dehydrosilybin B and/or their mixtures used in the prevention of cardiovascular, inflammatory, autoimmune and degenerative diseases based on bilirubin elevation, with the total content of 2,3-dehydrosilybin A, 2,3-dehydrosilybin B and/or their mixtures in the active ingredient of the prophylactic composition being at least 3% of the total weight.