Publikace na Matematicko-fyzikální fakulta |
2019
Abstrakt
We synthesize a novel prospective nanocomposite material for X-ray induced photodynamic therapy. ZnO:Ga core is coated by the SiO2 shell facilitating a functionalization by a photosensitizer, protoporphyrin PpIX layer.
By steady-state and time resolved spectroscopy we confirm the presence of energy transfer between the core and the photosensitizer, an essential requirement to induce a cytotoxic effect. Using the commercial chemical probe we also demonstrate the ability of prepared ZnO:Ga@SiO2-PpIX nanocomposite to generate singlet oxygen.
Presented results show that this nanocomposite can be considered as a good candidate for potential application in X-ray induced photodynamic therapy.