Exercise is one of the best medicines, being cheap andaccessible, with complex whole-body impact and veryfew side effects, and it is cost-effective.1,2Yet, persona-lised exercise prescription is not simple and comprisesmany challenges. Besides the lack of an adequate net-work of cardiac rehabilitation facilities in middle andlower-income countries alongside suboptimal referral inhigh-income countries, we also face low adherence ratesand non-responsiveness in patients adherence to exer-cise programmes.3In their article in this issue of theEuropeanJournal of Preventive Cardiology, Gevaert and col-leagues propose how to fill in the gaps to achieve amore personalised exercise prescription.4Such an indi-vidually targeted prescription would hopefully leadto more enjoyable and effective cardiovascularrehabilitation