Publication at Faculty of Medicine in Pilsen |
2020
Abstract
Actinic keratoses (AK), intraepithelial skin neoplasms, are reg-arded as field precursors of squamous cell carcinoma (SCC).1Fiveto ten percent of AKs progress to invasi ve SCC, with increasedrate of progression in patients with multiple lesions.2Due to thepotential risk of progression to invasive SCC, treatment at the ear-liest stage is recommended. AK lesions are mostly confined to thebasal layer of the epidermis and are less aggressive, characterizedby parakeratotic and orthokeratotic hyperkeratosis.