Publication at Third Faculty of Medicine, Faculty of Medicine in Hradec Králové |
2020
Abstract
Skin exanthema represents one of the most frequent adverse drug reactions. Pharmacologic and idiosyncratic (including allergic reaction especially after repeated exposition) reactions according to mechanisms are mentioned.
Four types of allergic reactions are distinguished - the IV. type is the most frequent (including the most severe epidermal necrolysis). The first step in patient's management is withdrawing of the drug.
Topical dermatological treatment depends on type of exanthema. Systemic therapy (antihistamins, steroids, immunosuppressives, IVIG, biologics) is used in severe cases.
The records to the patients documentation (allergy pass) are crucial for prevention of repeated adverse events.