Publication at Second Faculty of Medicine |
2020
Abstract
Hereditary angioedema is rare inherited disease presenting itself as edemas of different parts of the body. Most common type is caused by C1 inhibitor deficiency.
For the treatment of acute attacks we currently have available concentrates of human plasma-derived and recombinant C1 inhibitor and icatibant, which works as bradykinin receptor antagonist. For patients with frequent and severe attacks we use prophylactic treatment like danazol and tranexamic acid.
Recently lanadelumab, monoclonal antibody against kallikrein, became available too.