Low-dimensional compounds containing bioactive ligands. Part XV: Antiproliferative activity of tris(5-nitro-8-quinolinolato)gallium(III) complex with noticeable selectivity against the cancerous cells
Abstract
Three gallium(III) complexes, [Ga(NQ)(3)] (1), Na(3)[Ga(SQ)(3)].7H2O.3NaCl (2) and [Ga(CINQ)(3)].MeOH (3) were synthesised as possible anticancer agents (H-NQ= 5-nitro-8-quinolinol, H-SQH = 5-sulfo-8-quinolinol, H-CINQ= 5-chloro-7-nitro-8-quinolinol) and characterised by elemental analysis, IR and NMR spectroscopy. Single crystal structure analysis of 1 revealed two crystallographically independent [Ga(NQ)(3)] molecules in the asymmetric part of the unit cell.
Stability of the complexes 1 and 2 in solution was determined by (1)H NMR spectroscopy. Complex 3 was not further studied due to the low solubility.
Antiproliferative activity of complexes 1 and 2 was studied using in vitro MIT assay against the A2780, HCT116 and MDA-MB-231 cancer cell lines and the selectivity of the complexes was verified on non-cancerous MRCS pd30 cell line. Complex 1 showed high antiproliferative potency (IC(50) = 3.6 +/- 0.8 μM for HCT116) and noticeable selectivity of 1 against the cancer cell lines (IC(50) = 32 +/- 4 μM for normal MRCS pd30 cell line) was also found.
The complex 2 displayed the highest antioxidant activity of all tested complexes and free ligands.