Our group recently published in Clinical Anatomy an article describing the perineural spread of rectal cancer (Capek et al., 2014), but similar spread has been demonstrated in bladder (Aghion et al., 2014), prostate (Ladha et al., 2006; Hebert-Blouin et al., 2010), and cervical (Howe et al., 2013) cancers. We extended our understanding of this mechanism when we proposed that perineural spread provides an alternate explanation for regional osseous metastases.
We wonder whether the same hypothesis could explain regional metastases in the skeletal muscle.