Treatment of Granulomatosis with Polyangiitis and Microscopic Polyangiitis Should Type of ANCA Guide the Treatment?

Abstrakt

Granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA) are two major clinical entities recognized among ANCA-associated vasculitides. GPA and MPA differ in the presence or absence of granuloma, organ involvement, and risk of relapses.

GPA is more often, but not exclusively, associated with proteinase 3 (PR3)-ANCA, and MPA is more often, but not exclusively, associated with myeloperoxidase (MPO)-ANCA.

Klíčová slova

• ANCA
• vasculitis
• Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
• Antibodies
• Antineutrophil Cytoplasmic