A Study of the Correlation Structure of Microarray Gene Expression Data Based on Mechanistic Modeling of Cell Population Kinetics

Abstract

We consider the effect of heterogeneity on observed correlations between gene pairs within expression profiles. The effect of tissue heterogeneity on correlations is directly estimated for a simple two component model.

Then, a stochastic model of cell population kinetics is used to assess correlation effects for more complex mixtures. Finally, a mathematical model for correlation effects of subject-level heterogeneity is developed.

Keywords

• Study
• Correlation
• Structure
• Microarray
• Gene
• Expression
• Data
• Based
• Mechanistic
• Modeling
• Cell
• Population
• Kinetics