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Neuropsychiatric symptoms and creativity in neurodegenerative diseases

Publication at First Faculty of Medicine |
2020

Abstract

Neuropsychiatric symptoms (NS), such as de-pression, apathy, hallucinations, etc., as well as changes in creativity in older age, are tell-tale marks in the development of such neuro-degenerative diseases as Alzheimer's disease, frontotemporal lobar degeneration, Lewy body disease, and Parkinson's disease. Both NS and creativity are important non-cognitive aspects of behavior that changes as a result of neurodegen-eration, similar to the development of cognitive deficit.

NS can occur in the preclinical stages of neurodegeneration, as well as in the clinical stages (mild cognitive impairment or dementia). However, in clinical routine, their presence is underestimated, or patients with neurodegen-eration are often considered to have psychiatric disorders, which may negatively affect their treatment.

Scientific research is increasingly devoted to the analysis of the non-cognitive aspects of neurodegenerative diseases, resulting in the newly defined concept of Mild Behavioral Impairment (MBI). In this paper, a review of the most common NS and changes in creativity as a result of neurodegeneration with a special focus on Alzheimer's disease, frontotemporal lobar degeneration, Lewy body disease, and Parkin-son's disease is presented