Current treatment approaches in patients with newly diagnosed peripheral T-cell lymphoma and novel therapies-focusing on brentuximab vedotin
Abstract
Peripheral T-cell lymphoma (PTCL) is a rare disease with unfavourable prognosis except for low-risk patients with ALK (anaplastic lymphoma kinase)-positive anaplastic large T-cell lymphoma (ALCL). CHOP (cyclophosphamide, doxorubicin, vincristine and prednisone) was for many years the standard first line regimen.
Prognosis of patients failing first line therapy is extremely poor.. A recently published phase 3, randomised, double-blind, double dummy study (ECHELON-2) for newly diagnosed CD30-positive patients with PTCL has shown remarkable benefit of brentuximab vedotin (BV, chimeric anti-CD30 antibody with monomethyl auristatin E) when added to CHP chemotherapy in terms of significantly improved PFS as well as OS compared to standard therapy with CHOP, especially in ALCL patients.