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Response to Li and Hopper

Publication at Faculty of Medicine in Pilsen, First Faculty of Medicine |
2021

Abstract

We thank Drs. Li and Hopper for raising the important point of the possibly age-dependent effect of polygenic risk score (PRS) on colorectal cancer (CRC).

We would like totake thisopportunity toprovide the age-dependent hazard ratio (HR) estimate of the LDpred PRS (r 1/4 0.003) that was shown to perform the best in our paper.1