VERIFY study - how to ideally treat hyperglycemia of an uncomplicated diabetic at the beginning of the disease
Abstract
Gradual research has revealed many metabolic pathways, in the case of which the organism is unable to maintain glycemia in the optimal range, both on an empty stomach and ostprandially. This situation is well presented and also supports the theory that type 2 diabetes mellitus is not a single group of diseases, but from a pathophysiological point of view it is rather a heterogeneous set of different syndromes.
However, until a safe antidiabetic drug can be developed that is effective at the same time, free of serious side effects, and in particular does not cause hypoglycemia, these theoretical studies are rather out of the minds of clinicians (except for visionary exceptions). In retrospect, I wonder how it is even possible that diabetology has not learned from hypertensiologists.
Treatment of hypertension was initially directed linearly by increasing the dose of monotherapy. Also, the first attempts to treat hypertension with higher doses of hydrochlorothiazide led to negative results rather than miracles.
In this case, potassium was (probably) to blame. But gradually a completely rational concept of administration of several effective antihypertensives in combined and smaller doses has prevailed.
Anyone who can start using the potential of a fixed combination of perindopril, indapamide and amlodipine can now try it for themselves. In contrast, diabetology has not yet had a single truly representative study that would treat patients relatively young (about 50 years old) and beginning (with glycemia ranging from 6-7 mmol / l).
One job whose however, the result is not yet widely published, it was directed by prof. Fronza, however, was also designed with regard to pathophysiology.
But diabetes did come. VERIFY study.