Abstract
Urologic therapy with insufficiently selective alpha-blockers may be complicated by circulatory side effects, namely arterial hypotension and fluid retention. This tendency is markedly elevated in patients with cardiovascular disease.
In this report two cases of serious circulatory complications in cardiac patients treated with alpha blocker tamsulosin for lower urinary tract symptoms in benign prostatic hyperplasia are presented. In both cases the disappearance of side effects and normalization of clinical status was achieved after withdrawal of tamsulosin and its substitution by substantially more uroselective alpha1A-blocker silodosin.