Abstract
The effect of lysergic acid diethylamide (LSD) was studied in rats and mice by analysing chromosomes of primary spermatocytes. Male Wistar rats received a single close of LSD (10 or 1000 μg/kg b.w.).
The spermatocytes in diakinesis/ first metaphase were analysed on day 1, 7, 21 and 41 after the administration. ICR male mice were treated by a dose of 1000 μg LSD/kg b.w.
A testicular analysis was made after 12 weeks. Chromosomal breaks were sporadic and non-significant, with no chromosomal rearrangements.
A significant increase of spermatocytes, with univalents, in comparison with controls, was found in all experimental groups. Rats showed a distinct increase in the occurrence of spermatocytes with autosomal univalents; in mice there was an increased frequency of autosomal as well as X-Y univalents.