The 3rd V4 (i.e., Visegrad) international cystic fibrosis (CF) conference, held in November 2021 in Krakow, provided the opportunity to compare the availability of CFTR modulator (CFTRm) therapies in several Eastern European countries. Our interest in collecting the numbers of patients on CFTRm who live in this geographical region was primarily driven by concerns about the overall standards of CF care in less resourced countries, which if not accurate, have a substantial negative impact on CF health.