Gastrointestinal tract plays a key role in calcium and vitamin D metabolism, thus significantly participates in bone health. Diseases of the gastrointestinal tract, especially small intestine, pancreas and liver, are interwoven not only with disorders of the calcium and vitamin D metabolism, but also with higher incidence of osteoporosis and low-trauma fractures.
Common gastrointestinal medication can also interact with calcium absorption in the small intestine, and so increase the risk of osteoporosis.