Abstract
We identified the transmembrane protein CMTM4 as an essential component of the IL-17 receptor. CMTM4 is required for membrane expression of IL-17 receptor subunit C and activation of IL-17A pro-inflammatory signaling.
Lack of CMTM4 largely protects mice from experimental psoriasis, which suggests that targeting CMTM4 might alleviate IL-17-mediated autoimmunity.