Mjahed et al reported a very interesting case of accidental intra-arterial application of benzathine penicillin as a source of T9 through T10 spinal ischemia with the development of paraplegia and acute pulmonary edema. They implicated that an embolization of the Adamkiewicz artery, a nutritional vessel of T9 through T12 spinal cord levels, by crystals of penicillin salts, caused the spinal ischemia.
They suspected an immunologically mediated mechanism as a source of the noncardiogenic pulmonary edema. However, a subsequent allergologic examination was negative.