Management of Helicobacter pylori infection in paediatric patients in Europe: results from the EuroPedHp Registry
Abstract
Purpose: The EuroPedHp-registry aims to monitor guideline-conform management, antibiotic resistance, and eradication success of 2-week triple therapy tailored to antibiotic susceptibility (TTT) in Helicobacter pylori-infected children. Methods: From 2017 to 2020, 30 centres from 17 European countries reported anonymized demographic, clinical, antibiotic susceptibility, treatment, and follow-up data.
Multivariable logistic regression identified factors associated with treatment failure. Conclusions: Guideline-conform 2-weeks therapy PPI, amoxicillin, clarithromycin or metronidazole tailored to antibiotic suspectibility achieves primary eradication of >90%.
Higher failure rates in single-resistant strains despite tailored treatment indicate missed resistance by sampling error.