Abstract
Delayed (deferred) cord clamping represents the most physiologic method of placental transfusion. In case of adequate lung inflation (and uterine contractions) the increase in circulating blood volume facilitates postnatal cardiopulmonary adaptation and improves systemic oxygenation.
The changes lead to reduced mortality and risk of serious neonatal morbidities (intraventricular hemorrhage, hypotension requiring inotropic support, anemia of prematurity) with improved neurodevelopmental outcome in preterm infants. The authors present an overview of physiology and pathophysiology of placental transfusion, its methods and impact on neonatal morbidity and long-term outcome.
Up-to-date international recommendations regarding the management of placental transfusion are also included.