Complementary strategies for synthesis of sulfinamides from sulfur-based feedstock

Abstract

We describe a straightforward one-pot reductive protocol for the synthesis of sulfinamides from sulfonyl chlorides. This method enables the preparation of sulfinamides with a broad range of functional groups.

Furthermore, we have expanded a known oxidative pathway to sulfinamides starting from thiols. These methods together provide a general strategy for the synthesis of sulfinamides from common sulfur-based feedstock that is available with large structural and functional group diversity.

Keywords

• ONE-POT SYNTHESIS
• ASYMMETRIC-SYNTHESIS
• GENERAL-METHOD
• IN-VITRO
• CHLORIDES
• REAGENTS
• THIOLS
• ACIDS