Alteration of methotrexate biliary and renal elimination during extrahepatic and intrahepatic cholestasis in rats

Abstract

The aim of this study was to evaluate changes in methotrexate, an important anticancer and immunosuppressive agent, biliary and renal excretion during either intrahepatic or obstructive cholestasis in rats.

Keywords

• methotrexate
• cholestasis
• pharmacokinetics
• conjugated bilirubin
• drug transporter