Levels of soluble forms of E-, P-selectin, endotelin-1 and monocyte chemotactic protein (MCP-1) were examined in the process of extracorporeal cholesterol elimination by LDL-apheresis. It is an increased level of P-selectin in the blood of patients with FH in spite of long-term intensive treatment.
Immediately after the LDL-apheresis decreases P-selectin, MCP-1 and endotelin-1 significantly.