Weekly Paclitaxel Combined with Local hyperthermia in the Therapy of Breast Cancer Locally recurrent after Mastectomy - a Pilot Experience
2004
Abstract
The combination of chemotherapy and hyperthermia (HT) is a promising approach in the treatment of malignant tumors. In the present report we evaluate the efficacy and toxicity of a combination of weekly paclitaxel combined with local hyperthermia in breast cancer.
Patients and Methods: 7 patients were treated for inoperable local recurrence of breast cancer after mastectomy, irradiation, and chemotherapy or hormonal therapy. They weekly received paclitaxel (60-80 mg/m2) in 3-h infusions followed by local HT 41-44 °C for 45 min for 6-18 cycles.
Conclusion: Our experience indicates that the combination of weekly paclitaxel and HT may be effective in the treatment of locally recurrent breast cancer after mastectomy.