Abstract
Venous thromboembolism is still major medicinal problem. In the last couple of years, the significant progress concerning the etiopathogesis of this disease has been made, which could enable us to explain the cause of many cases of venous thrombosis, mainly with the familiar occurrence.
The knowledge of criteria of the indication for thrombophilia work-up and especially pragmatic clinical interpretation of results are very important. These results together with perfect knowledge of family and personal history of venous thrombosis can help us to assess thrombophilic potential of every individual and enable us to choose the correct strategy of thromboprophylaxis.