The authors described a rare case of spontaneous repositioning of an embolised Amplatzer occluder into the left atrium resulting in complete occlusion of a hemodynamically significant atrial septal defect, in the fossa ovalis, in a 70-year-old man. Only a slight central residual shunting was present, as was shown by transesophageal Doppler echocardiography performed immediately after the procedure, with no apparent shunt at 30, 60 and 120 days after the intervention.