Publication at First Faculty of Medicine |
2003
Abstract
The in vitro fission of D,L-mevalonic acid with 50 % sulphuric acid at 100 °C resulted in the formation of isoprene identified by gas chromatography ? mass spectrometry. When the same reaction was performed with D,L-mevalonolactone-2-13C two types of isoprene isomers were distinguished in the mass spectra: isoprene with the 13C carbon atom in position 1 or in the methyl group, resp.
These isomers were formed in the ratio 2:1. The experimental results were compared with selected quantum chemical calculations and were found to be in agreement with the common knowledge of dehydration reactions.