Abstract
Estrogen deficit in postmenopausal women has been known for a long time as the main precipitating factor of increased bone resorption, increased loss of bone tissue and bone minerals and following postmenopausal osteoporosis. Only the last decades have contributed significantly to learning and understanding the mechanisms by which estrogens influence the metabolisms of bone cells.
It is proven that the estrogens and also their deficit markedly influence mainly the production of osteoclasts, the length of their lives, function and regulation. There are many hormones and agents that bring on increased osteoclastogenesis.