Aim: To analyse the factors which influence global quality of life in patients after the hematopoietic stem cell transplantation at the Department of Clinical Hematology of the Second Internal Clinic of the University Hospital and Medical Faculty of Charles University in Hradec Kralove, Czech Republic. Conclusion: The global quality of life in patients who underwent the hematopoietic stem cell transplantation at the Department of Clinical Hematology of the Second Internal Clinic of the University Hospital and Medical Faculty of Charles University in Hradec Kralove, Czech Republic, is very high, which is seen from EQ-5D index (72.5%) and EQ-5D VAS (76.5%) values.