Abstract
Urgent angiographic examination, followed by interventional treatment, is nowadays a routine procedure in patients with acute coronary syndrome (ACS). The physician faces the task of identifying the narrowing responsible for the ACS and the interventional treatment implies the treatment of the identified lesion.
It appears however, that ACS is associated with the activation of circulating platelets, monocytes and leukocytes, with increasing markers of interaction of the circulating elements (soluble tissue factor, inhibitor of tissue factor, soluble liganda CD 40) and with higher level of circulating metalloproteinase. Multiple occurrences of ?culprit lesions? in patients with ACS have been repeatedly documented.
The authors ask how often the narrowing responsible for the development of ACS and how often the multiple damages leading to ACS can be unambiguously identified. The assessment of consecutive diseases shows the prevailing occurrence of multiple lesions in patients with ACS.
