Publication at First Faculty of Medicine |
2004
Abstract
Objective: Somatic mutations in the Ki-ras gene are believed to be an important pathogenetic event occurring approximately in the middle of the neoplastic cascade in the colon. These genetic changes have been observed in about 40%of resected colorectal carcinomas and in 20?60%of benign colon adenomas.
In this studywe analyzed the presence of Ki-ras gene mutations in bioptic specimens of colorectal tumours and polyps.Conclusion: Taking into account aggressivity of some Ki-ras mutations, a proper DNA analysis could contribute to improvement of laboratory diagnostics of cancer, especially in subjects at a higher risk for colorectal carcinoma.