Abstract
The origin of these pathogenic microbs is in wild animals which were domesticated during neolitic revolution. Innate immunity is able to identify pathogen associated molecular patterns of pathogenic microorganisms by various receptors for pathogen patterns.
Adaptive immunity protects people effectively during repeated exposure to the same microbial agent. Exposure to the both pathogenic and nonpathogenic microbs is the principal evolutionary selection mechanism.
The influence of microbs on individual and populational level is significantly changed by the application of antibiotics. Their application results in the disturbance of individual physiological microflora.
This change together with deminished environmental microbial load results into adverse effect on ontogenetical development of immune system. This gradual loss of mutual relationship between microbs and people is very likely one from the reasons for rapid increase in the incidence of autoimmune immunopathological diseases such as allergies.