Gamma-radiation-induced ATM-dependent signalling in human T-lymphocyte leukemic cells, MOLT-4

Abstract

ATM kinase (ATM) is essential for activation of cell cycle check points and DNA repair in response to ionizing radiation (IR). In this work we studied the molecular mechanisms regulationg DNA repair and cell death in human T-lymphocyte leukemic cells, MOLT-4.

Keywords

• ATM kinase
• checkpoint kinase-2
• p53
• Mdm2
• ionizing radiation