Publication at First Faculty of Medicine |
2006
Abstract
Interstitial microdialysis is a minimally invasive method that allows biochemical monitoring of endogenous and exogenous substances in extracellular tissue space. The method is based on sampling of soluble molecules from the interstitial space fluid by means of a semipermeable membrane.
Microdialysis has been applied in primary and clinical research of metabolic changes and the blood flow in tissue interstitium and pharmacokinetic drug studies. Findings yielded by microdialysis are gradually finding their place in clinical practice as well.
This paper aims at presenting to the reader a new technique of monitoring interstitial metabolism, its advantages and drawbacks and potential application in medicine.