Glycation and advanced glycation end-products in laboratory experiments in vivo and vitro

Abstract

The purpose of our study was to determine the amount of glycated proteins and advanced glycation and products (AGE) om cataractous lens homogenates of patients who underwent phacoemulsification , and to define a simple in vitro protein model glycation.Our data:i) support the concept of glycation-glycoxidation pathway appearing in diabetes patients;ii)form a base for determination of the efficiency of various antioxidative compounds in vitro.

Keywords

• glycoxidation
• glycation
• diabetes
• lens
• AGE
• fluorescence
• protein
• ALT
• AST
• catalytic activityP