Low-dose methotrexate pharmacokinetics and pharmacodynamics in the therapy of severe psoriasis

Abstract

41 patients with psoriasis were treated with 7,5 mg or 15 mg MTX administered once a week. The pharmacokinetic of MTX were evaluated at week 1 and 13, MTX in erythrocytes and the PASI-score were evaluated repeatedly.

There was a strong correlation between MTX AUC at week 1 and PASI at week 13 (rho = -0,08, p 0,0001).

Keywords

• methotrexate
• psoriasis
• pharmacokinetics