Osteoadherin is upregulated by mature osteoblasts and enhances their in vitro differentiation and mineralization

Abstract

The influence of osteoadherin (OSAD) on the behavior and maturation of MC3T3E1 osteoblasts was investigated with plasmids coding for either mouse OSAD cDNA or small-hairpin RNA. We concluded that OSAD overexpression enhanced the differentiation and maturation of osteoblasts in vitro.

Keywords

• osteoadherin
• overexpression