Publication at Faculty of Physical Education and Sport, Faculty of Medicine in Hradec Králové |
2009
Abstract
Newborn are well- known to have the value of drug clearance different from those seen in children and adults. Much of this difference is attributable to the maturational covariates.
Little information is available regarding the disposition of antimicrobial agents in the neonatal population in spite of the fact that carbapenems (including meropenem for instance) are often life-saving and the proper dosing interval should maximize the time of plasma concentrations above the MIC (Time>MIC) important for clinical antimicrobial effectivity.