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ellipticine–DNA adduct formation
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Peroxidase-mediated ellipticine-DNA adduct formation explains the selective efficiency of this anticancer drug against breast cancer and leukemia
2003 |
Přírodovědecká fakulta
publication
Peroxidase-mediated ellipticine-DNA adduct formation explains the selective efficiency of this anticancer drug against breast cancer and leukemia
2003 |
1. lékařská fakulta, Matematicko-fyzikální fakulta
publication
Peroxidase and CYP-mediated ellipticine-DNA adduct formation explains the selective efficiency of this anticancer drug against breast cancer and leukemia
2003 |
Přírodovědecká fakulta
publication
Peroxidase and CYP-mediated ellipticine-DNA adduct formation explains the selective efficiency of this anticancer drug against breast cancer and leukemia
2003 |
1. lékařská fakulta, Matematicko-fyzikální fakulta
publication
Ellipticine oxidation and DNA adduct formation in human hepatocytes is catalyzed by human cytochromes P450 and enhanced by cytochrome b5
2012 |
Přírodovědecká fakulta
publication
The Hepatic Reductase Null (HRN (TM)) and Reductase Conditional Null (RCN) mouse models as suitable tools to study metabolism, toxicity and carcinogenicity of environmental pollutants
2015 |
Přírodovědecká fakulta
publication
Application of hepatic cytochrome b(5)/P450 reductase null (HBRN) mice to study the role of cytochrome b(5) in the cytochrome P450-mediated bioactivation of the anticancer drug ellipticine
2019 |
Přírodovědecká fakulta
publication
Cytochrome b(5) shifts oxidation of the anticancer drug ellipticine by cytochromes P450 1A1 and 1A2 from its detoxication to activation, thereby modulating its pharmacological efficacy
2011 |
Přírodovědecká fakulta
publication
Anticancer agent ellipticine combined with histone deacetylase inhibitors, valproic acid and trichostatin A, is an effective DNA damage strategy in human neuroblastoma
2011 |
2. lékařská fakulta