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cellular models
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Study on 99mTc-MAG3 and 99mTc-DMSA renal accumulation using in vitro cellular model
2011 |
Faculty of Pharmacy in Hradec Králové
publication
The CRISPR-Cas9 crATIC HeLa transcriptome: Characterization of a novel cellular model of ATIC deficiency and ZMP accumulation
2020 |
First Faculty of Medicine
publication
Expression of enzymes of metabolic activation of PAHs in rat liver cellular models
Publication without faculty affiliation
publication
Molecular characterization of the AdeI mutant of Chinese hamster ovary cells: A cellular model of adenylosuccinate lyase deficiency
2011 |
First Faculty of Medicine
publication
Interdisciplinary approach to molecular basis of inherited metabolic disorders (IMD)
Publication without faculty affiliation
publication
Genetic and metabolomic analysis of AdeD and AdeI mutants of de novo purine biosynthesis: Cellular models of de novo purine biosynthesis deficiency disorders
2013 |
First Faculty of Medicine
publication
Validation of Freshly Isolated Rat Renal Cells as a Tool for Preclinical Assessment of Radiolabeled Receptor-Specific Peptide Uptake in the Kidney
2023 |
Faculty of Pharmacy in Hradec Králové
publication
CRISPR-Cas9 induced mutations along de novo purine synthesis in HeLa cells result in accumulation of individual enzyme substrates and affect purinosome formation
2016 |
First Faculty of Medicine
publication
Cucurbitacin E Has Neuroprotective Properties and Autophagic Modulating Activities on Dopaminergic Neurons
2014 |
Faculty of Pharmacy in Hradec Králové
publication
Ensartinib (X-396) Effectively Modulates Pharmacokinetic Resistance Mediated by ABCB1 and ABCG2 Drug Efflux Transporters and CYP3A4 Biotransformation Enzyme
2020 |
Faculty of Pharmacy in Hradec Králové
publication
2-Propargylamino-naphthoquinone derivatives as multipotent agents for the treatment of Alzheimer's disease
2021 |
Publication without faculty affiliation
publication
Missense mutation in RPS7 causes Diamond-Blackfan anemia via alteration of erythrocyte metabolism, protein translation and induction of ribosomal stress
2022 |
Central Library of Charles University
publication
The CRISPR-Cas9 crADSL HeLa transcriptome: A first step in establishing a model for ADSL deficiency and SAICAR accumulation
2019 |
First Faculty of Medicine
publication
Analysis of 5-Azacytidine Resistance Models Reveals a Set of Targetable Pathways
2022 |
First Faculty of Medicine
publication
Transcriptome and metabolome analysis of crGART, a novel cell model of de novo purine synthesis deficiency: Alterations in CD36 expression and activity
2021 |
First Faculty of Medicine
publication
Mitochondrial organization and structure are compromised in fibroblasts from patients with Huntington's disease
2022 |
First Faculty of Medicine
publication
Exploring the molecular mechanisms used by human BK polyomavirus to activate immune responses in "reservoir cells"
Publication without faculty affiliation
publication
In Vitro and In Vivo Experimental Hepatotoxic Models in Liver Research: Applications to the Assessment of Potential Hepatoprotective Drugs
2016 |
First Faculty of Medicine
publication
Organoids as a personalized medicine tool for ultra-rare mutations in cystic fibrosis: The case of S955P and 1717-2A > G
2020 |
Second Faculty of Medicine
publication
Inhibition of AKR1B10-mediated metabolism of daunorubicin as a novel off-target effect for the Bcr-Abl tyrosine kinase inhibitor dasatinib
2021 |
Faculty of Pharmacy in Hradec Králové
publication
The Use of the LanthaScreen TR-FRET CAR Coactivator Assay in the Characterization of Constitutive Androstane Receptor (CAR) Inverse Agonists
2015 |
Faculty of Pharmacy in Hradec Králové
publication
The in vivo disposition and in vitro transmembrane transport of two model radiometabolites of DOTA-conjugated receptor-specific peptides labelled with Lu-177
2015 |
Faculty of Pharmacy in Hradec Králové
publication
Olaparib Synergizes the Anticancer Activity of Daunorubicin via Interaction with AKR1C3
2020 |
Faculty of Pharmacy in Hradec Králové
publication
Entecavir Interacts with Influx Transporters hOAT1, hCNT2, hCNT3, but Not with hOCT2: The Potential for Renal Transporter-Mediated Cytotoxicity and Drug-Drug Interactions
2016 |
Faculty of Pharmacy in Hradec Králové
publication
X-Chromosome Inactivation Analysis in Different Cell Types and Induced Pluripotent Stem Cells Elucidates the Disease Mechanism in a Rare Case of Mucopolysaccharidosis Type II in a Female
2016 |
First Faculty of Medicine
publication
Mathematical Models in the Description of Pregnane X Receptor (PXR)-Regulated Cytochrome P450 Enzyme Induction
2018 |
Faculty of Pharmacy in Hradec Králové, Faculty of Science
publication
Cytochrome c Oxidase Subunit 4 Isoform Exchange Results in Modulation of Oxygen Affinity
2020 |
Faculty of Science
publication
Talazoparib Does Not Interact with ABCB1 Transporter or Cytochrome P450s, but Modulates Multidrug Resistance Mediated by ABCC1 and ABCG2: An in Vitro and Ex Vivo Study
2022 |
Faculty of Pharmacy in Hradec Králové, Faculty of Medicine in Hradec Králové
publication
Brivanib Exhibits Potential for Pharmacokinetic Drug-Drug Interactions and the Modulation of Multidrug Resistance through the Inhibition of Human ABCG2 Drug Efflux Transporter and CYP450 Biotransformation Enzymes
2019 |
Faculty of Pharmacy in Hradec Králové
publication
Entrectinib reverses cytostatic resistance through the inhibition of ABCB1 efflux transporter, but not the CYP3A4 drug-metabolizing enzyme
2020 |
Faculty of Pharmacy in Hradec Králové