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human liver microsomes
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2C-B-Fly-NBOMe Metabolites in Rat Urine, Human Liver Microsomes and C. elegans: Confirmation with Synthesized Analytical Standards
2021 |
Central Library of Charles University
publication
Purification of novel human liver microsomal carbonyl reductase
Publication without faculty affiliation
publication
UHPLC-Orbitrap study of the first phase tacrine in vitro metabolites and related Alzheimer's drug candidates using human liver microsomes
2023 |
Faculty of Pharmacy in Hradec Králové
publication
Carboxylesterase 1 - human liver microsomal carbonyl reductase?
Publication without faculty affiliation
publication
Anthracyclines and their metabolism in human liver microsomes and the participation of the new microsomal carbonyl reductase
2011 |
Faculty of Pharmacy in Hradec Králové
publication
The metabolism of paclitaxel in rat and human liver microsomes as inhibited by phenolic antioxidants
2002 |
Faculty of Science
publication
The metabolism of paclitaxel in rat and human liver microsomes as inhibited by phenolic antioxidants
2002 |
First Faculty of Medicine, Faculty of Mathematics and Physics
publication
Interaction of memantine with human liver microsomal cytochrome P450: inhibition of CYP2D6
Publication without faculty affiliation
publication
25CN-NBOMe Metabolites in Rat Urine, Human Liver Microsomes and C. elegans-Structure Determination and Synthesis of the Most Abundant Metabolites
2021 |
Central Library of Charles University
publication
Effect of memantine on in vitro cytochrome P450- mediated metabolic activities in human liver microsomes
2003 |
Faculty of Medicine in Hradec Králové
publication
Metabolic activation of 3-aminobenzanthrone by human liver microsomes and by human recombinant cytochromes P450
Publication without faculty affiliation
publication
Interaction of isoflavonoids with human liver microsomal cytochromes P450: inhibition of CYP enzyme activities
2017 |
Faculty of Science
publication
Enantiospecific effects of chiral drugs on cytochrome P450 inhibition in vitro
2016 |
Faculty of Pharmacy in Hradec Králové
publication
The New Acetylcholinesterase Inhibitors PC-37 and PC-48 (7-Methoxytacrine-Donepezil-Like Compounds): Characterization of Their Metabolites in Human Liver Microsomes, Pharmacokinetics and In Vivo Formation of the Major Metabolites in Rats
2018 |
Faculty of Medicine in Hradec Králové
publication
The Main Metabolic Pathway of Oracin, a New Potential Cytostatic Drug, in Human Liver Microsomes and Cytosol: Stereoselectivity of Reoxidation of the Principal Metabolite 11-Dihydrooracin to Oracin
2000 |
Faculty of Pharmacy in Hradec Králové
publication
The Role of Cytochromes P450 and Aldo-Keto Reductases in Prognosis of Breast Carcinoma Patients
2014 |
First Faculty of Medicine, Second Faculty of Medicine
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Cytochrome b(5) impacts on cytochrome P450-mediated metabolism of benzo[a]pyrene and its DNA adduct formation: studies in hepatic cytochrome b(5)/P450 reductase null (HBRN) mice
2018 |
Faculty of Science
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Purification and characterisation of membrane bound reductase from human liver tissue
Publication without faculty affiliation
publication
Inhibitory effects of memantine on human cytochrome P450 activities: prediction of in vivo drug interactions
2004 |
Faculty of Medicine in Hradec Králové
publication
Partial purification and characterization of new human membrane-bound carbonyl reductase playing a role in the deactivation of the anticancer drug oracin
2009 |
Central Library of Charles University
publication
Partial purification and characterization of new human membrane-bound carbonyl reductase playing a role in the deactivation of the anticancer drug oracin
2009 |
Faculty of Pharmacy in Hradec Králové
publication
Evaluation of possible inhibition of human liver drug metabolizing cytochromes P450 by two new acetylcholinesterase oxime-type reactivators
2016 |
Publication without faculty affiliation
publication
In vitro metabolism of helenalin and its inhibitory effect on human cytochrome P450 activity
2022 |
Faculty of Pharmacy in Hradec Králové
publication
Potent and Selective Human Neuronal Nitric Oxide Synthase Inhibition by Optimization of the 2-Aminopyridine-Based Scaffold with a Pyridine Linker
2016 |
First Faculty of Medicine
publication
Tacrine-Trolox Hybrids: A Novel Class of Centrally Active, Nonhepatotoxic Multi-Target-Directed Ligands Exerting Anticholinesterase and Antioxidant Activities with Low In Vivo Toxicity
2015 |
Publication without faculty affiliation
publication
Novel 2,4-Disubstituted Pyrimidines as Potent, Selective, and Cell-Permeable Inhibitors of Neuronal Nitric Oxide Synthase
2015 |
First Faculty of Medicine
publication
Influence of Amlodipine Enantiomers on Human Microsomal Cytochromes P450: Stereoselective Time-Dependent Inhibition of CYP3A Enzyme Activity
2017 |
Faculty of Pharmacy in Hradec Králové
publication
Beta-caryophyllene Oxide and Trans-nerolidol Affect Enzyme Activity of CYP3A4-In Vitro and In Silico Studies
2019 |
Faculty of Pharmacy in Hradec Králové
publication
Pelargonidin activates the AhR and induces CYP1A1 in primary human hepatocytes and human cancer cell lines HepG2 and LS174T
2013 |
Faculty of Pharmacy in Hradec Králové
publication
Antimycobacterial pyridine carboxamides: From design to in vivo activity
2023 |
Faculty of Pharmacy in Hradec Králové